Energy Efficient Relay-Assisted Cellular Network Model using Base Station Switching

Cellular network planning strategies have tended to focus on peak traffic scenarios rather than energy efficiency. By exploiting the dynamic nature of traffic load profiles, the prospect for greener communications in cellular access networks is evolving. For example, powering down base stations (BS) and applying cell zooming can significantly reduce energy consumption, with the overriding design priority still being to uphold a minimum quality of service (QoS). Switching off cells completely can lead to both coverage holes and performance degradation in terms of increased outage probability, greater transmit power dissipation in the up and downlinks, and complex interference management, even at low traffic loads. In this paper, a cellular network model is presented where certain BS rather than being turned off, are switched to low-powered relay stations (RS) during zero-to-medium traffic periods. Neighbouring BS still retain all the baseband signal processing and transmit signals to corresponding RS via backhaul connections, under the assumption that the RS covers the whole cell. Experimental results demonstrate the efficacy of this new BS-RS Switching technique from both an energy saving and QoS perspective, in the up and downlinks

Energy savings using an adaptive base station-to-relay station switching paradigm

Applying a Base Station (BS) sleep approach during low traffic periods has recently been advocated as a strategy for reducing energy consumption in cellular networks. The complete switching off of certain BS however, can lead to coverage holes and severe performance degradation in terms of off-cell user throughput, greater transmit power dissipation in both the up and downlinks, and more complex interference management. This paper presents a novel cellular network energy saving model in which certain BS rather being turned off are switched to Relay Station (RS) mode during low traffic periods. The switched RS and other shared RS deployed at the cross border of each cell are responsible for upholding the same quality of service (QoS) provision as when all BS are active. A centralised adaptive switching threshold algorithm is also introduced to undertake the switching decision, instead of using a fixed threshold. Simulation results confirm the new BS-RS Switching model using an adaptive threshold can reduce network energy consumption by more than half, as well as improving off-cell users’ throughput

Traffic-and-interference aware base station switching for green cellular networks

Base station (BS) sleeping in cellular networks has emerged as a promising solution for more energy efficient communications, concomitant with lowering the network carbon footprint. Switching off specific BS entirely however, can lead to coverage holes and severe performance degradation. To avoid coverage holes, the transmit power of neighbouring BS must be commensurately increased, which can cause higher interference to other cell users. Recently a BS-RS (relay station) switching model has been proposed where the BS changes operating mode to a RS during off-peak periods rather than being completely turned off. This paper presents a traffic-aware and traffic-and-interference aware switching strategy for both the BS sleeping and BS-RS switching paradigms, which dynamically establishes the conditions for a BS to alter its working mode. The switching is based upon a dynamic traffic threshold allied with the received BS interference level. Analysis corroborates both new algorithms significantly improve network energy efficiency, while upholding the requisite quality of service provision

Dynamic spectrum access based on cognitive radio within cellular networks

Overlay transmissions in cognitive radio (CR) permit a secondary system to use spectrum concomitantly with a primary system, though adopting this spectrum sharing strategy presents a number of challenges, such as the requirement for a secondary user to have a priori knowledge as side information about the primary user. In this paper, a cognitive cellular network is proposed which uses an overlay approach to dynamically share its radio resource by incorporating cognition, leading to enhanced cell capacity. To compensate for the interference caused by the overlay, cognitive base stations use robust dirty-paper coding in combination with variable transmission powers, which are set depending upon the location of the mobile stations. A detailed performance analysis is presented to corroborate the improved spectrum utilization achieved using this technique

An interference-aware virtual clustering paradigm for resource management in cognitive femtocell networks

Femtocells represent a promising alternative solution for high quality wireless access in indoor scenarios where conventional cellular system coverage can be poor. They are randomly deployed by the end user, so only post deployment network planning is possible. Furthermore, this uncoordinated deployment creates severe interference to co-located femtocells, especially in dense deployments. This paper presents a new architecture using a generalised virtual cluster femtocell (GVCF) paradigm, which groups together FAP into logical clusters. It guarantees severely interfering and overlapping femtocells are assigned to different clusters. Since each cluster operates on different band of frequencies, the corresponding virtual cluster controller only has to manage its own FAPs, so the overall system complexity is low. The performance of the GVCF algorithm is analysed from both a resource availability and cluster number perspective. Simulation results conclusively corroborate the superior performance of the GVCF model in interference mitigation, particularly in high density FAP scenarios

Novel instrumented frame for standing exercising of users with complete spinal cord injuries

This paper describes a Functional Electrical Stimulation (FES) standing system for rehabilitation of bone mineral density (BMD) in people with Spinal Cord Injury (SCI). BMD recovery offers an increased quality of life for people with SCI by reducing their risk of fractures. The standing system developed comprises an instrumented frame equipped with force plates and load cells, a motion capture system, and a purpose built 16-channel FES unit. This system can simultaneously record and process a wide range of biomechanical data to produce muscle stimulation which enables users with SCI to safely stand and exercise. An exergame provides visual feedback to the user to assist with upper-body posture control during exercising. To validate the system an alternate weight-shift exercise was used; 3 participants with complete SCI exercised in the system for 1 hour twice-weekly for 6 months. We observed ground reaction forces over 70% of the full body-weight distributed to the supporting leg at each exercising cycle. Exercise performance improved for each participant by an increase of 13.88 percentage points of body-weight in the loading of the supporting leg during the six-month period. Importantly, the observed ground reaction forces are of higher magnitude than other studies which reported positive effects on BMD. This novel instrumentation aims to investigate weight bearing standing therapies aimed at determining the biomechanics of lower limb joint force actions and postural kinematics

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials

Objectives. To investigate the safety and immunogenicity of boosting BCG with modified vaccinia Ankara expressing antigen 85A (MVA85A), shortly after BCG vaccination, and to compare this first with the immunogenicity of BCG vaccination alone and second with a previous clinical trial where MVA85A was administered more than 10 years after BCG vaccination. Design. There are two clinical trials reported here: a Phase I observational trial with MVA85A; and a Phase IV observational trial with BCG. These clinical trials were all conducted in the UK in healthy, HIV negative, BCG naı¨ve adults. Subjects were vaccinated with BCG alone; or BCG and then subsequently boosted with MVA85A four weeks later (short interval). The outcome measures, safety and immunogenicity, were monitored for six months. The immunogenicity results from this short interval BCG prime–MVA85A boost trial were compared first with the BCG alone trial and second with a previous clinical trial where MVA85A vaccination was administered many years after vaccination with BCG. Results. MVA85A was safe and highly immunogenic when administered to subjects who had recently received BCG vaccination. When the short interval trial data presented here were compared with the previous long interval trial data, there were no significant differences in the magnitude of immune responses generated when MVA85A was administered shortly after, or many years after BCG vaccination. Conclusions. The clinical trial data presented here provides further evidence of the ability of MVA85A to boost BCG primed immune responses. This boosting potential is not influenced by the time interval between prior BCG vaccination and boosting with MVA85A. These findings have important implications for the design of efficacy trials with MVA85A. Boosting BCG induced anti-mycobacterial immunity in either infancy or adolescence are both potential applications for this vaccine, given the immunological data presented here. Trial Registration. ClinicalTrials.Oxford University was the sponsor for all the clinical trials reported here

Factors associated with self-reported number of teeth in a large national cohort of Thai adults

<p>Abstract</p> <p>Background</p> <p>Oral health in later life results from individual's lifelong accumulation of experiences at the personal, community and societal levels. There is little information relating the oral health outcomes to risk factors in Asian middle-income settings such as Thailand today.</p> <p>Methods</p> <p>Data derived from a cohort of 87,134 adults enrolled in Sukhothai Thammathirat Open University who completed self-administered questionnaires in 2005. Cohort members are aged between 15 and 87 years and resided throughout Thailand. This is a large study of self-reported number of teeth among Thai adults. Bivariate and multivariate logistic regressions were used to analyse factors associated with self-reported number of teeth.</p> <p>Results</p> <p>After adjusting for covariates, being female (OR = 1.28), older age (OR = 10.6), having low income (OR = 1.45), having lower education (OR = 1.33), and being a lifetime urban resident (OR = 1.37) were statistically associated (p < 0.0001) with having less than 20 teeth. In addition, daily soft drink consumptions (OR = 1.41), current regular smoking (OR = 1.39), a history of not being breastfed as a child (OR = 1.34), and mother's lack of education (OR = 1.20) contributed significantly to self-reported number of teeth in fully adjusted analyses.</p> <p>Conclusions</p> <p>This study addresses the gap in knowledge on factors associated with self-reported number of teeth. The promotion of healthy childhoods and adult lifestyles are important public health interventions to increase tooth retention in middle and older age.</p

Impact on Malaria Parasite Multiplication Rates in Infected Volunteers of the Protein-in-Adjuvant Vaccine AMA1-C1/Alhydrogel+CPG 7909

BACKGROUND: Inhibition of parasite growth is a major objective of blood-stage malaria vaccines. The in vitro assay of parasite growth inhibitory activity (GIA) is widely used as a surrogate marker for malaria vaccine efficacy in the down-selection of candidate blood-stage vaccines. Here we report the first study to examine the relationship between in vivo Plasmodium falciparum growth rates and in vitro GIA in humans experimentally infected with blood-stage malaria. METHODS: In this phase I/IIa open-label clinical trial five healthy malaria-naive volunteers were immunised with AMA1/C1-Alhydrogel+CPG 7909, and together with three unvaccinated controls were challenged by intravenous inoculation of P. falciparum infected erythrocytes. RESULTS: A significant correlation was observed between parasite multiplication rate in 48 hours (PMR) and both vaccine-induced growth-inhibitory activity (Pearson r = -0.93 [95% CI: -1.0, -0.27] P = 0.02) and AMA1 antibody titres in the vaccine group (Pearson r = -0.93 [95% CI: -0.99, -0.25] P = 0.02). However immunisation failed to reduce overall mean PMR in the vaccine group in comparison to the controls (vaccinee 16 fold [95% CI: 12, 22], control 17 fold [CI: 0, 65] P = 0.70). Therefore no impact on pre-patent period was observed (vaccine group median 8.5 days [range 7.5-9], control group median 9 days [range 7-9]). CONCLUSIONS: Despite the first observation in human experimental malaria infection of a significant association between vaccine-induced in vitro growth inhibitory activity and in vivo parasite multiplication rate, this did not translate into any observable clinically relevant vaccine effect in this small group of volunteers. TRIAL REGISTRATION: ClinicalTrials.gov [NCT00984763]